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While none have yet received official approval, ongoing clinical trials may pave the way for targeted treatments in the future

Investigators have described this pattern as a "broad reset" of pathways associated with cellular aging language that, while evocative, remains pre-clinical and has not been translated into validated human therapeutic claims

p62 activators Two compounds able to increase p62 levels, trehalose and rapamycin, have been demonstrated to increase nuclear translocation of NRF2 in a p62-dependent manner and to enhance expression of its downstream antioxidant factors, HO1 and NQO1, in a hepatoma cellular system [308] and in a preclinical model of FRDA [309]