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Furthermore, the model confirmed the potent antioxidant capacity of DEC, as evidenced by reduced ROS levels and upregulated Nrf2 expression, suggesting effective dermal penetration and activation of endogenous protective mechanisms

As most differentially spliced Ubx-targets in embryonic mesoderm are exclusively spliced 21 , we extended our investigation to elucidate the mechanism regulating this important gene class, relying on the Ubx WT /Ubx N51A interaction