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A gastric gavage with 150 mg glucose increased circulating levels of glucose and insulin and 8 week pretreatment with NVP DPP728 reduced the increase in glucose and augmented the increase in insulin ( Figure 2 First Clinical Study The first clinical study with a DPP-4 inhibitor was performed with NVP DPP728 at five centers in Sweden and involved 93 patients with mild drug-naive type 2 diabetes (61 men and 32 women)

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showed that the autoimmune reaction against HSP60 is the initial event of AS (Wick et al., 1995

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