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A thorough medical assessment will help identify whether weight management treatment is appropriate, which options are safest for your individual circumstances, and whether any underlying conditions may be affected

For example, individuals with significant liver dysfunction or other medical issues may require a more tailored approach to therapy

Systemic insulin resistance and consequent dysregulation in homeostatic glycaemic status are the key mediators of the chronic complications associated with uncontrolled T2DM and metabolic syndrome, both in the form of microvascular disease (retinopathy, neuropathy, nephropathy) and macrovascular complications (stroke and coronary artery disease) [206,207]

Studies in isolated rat muscle

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