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We circumvented the need for CYP-mediated bioactivation of AQ and DEAQ by exposing the cells to the synthetic AQ-QI and DEAQ-QI, the reactive metabolites of AQ

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Given these facts, our findings may support the idea that giving LS and GSH, in their traditional and NP forms, either alone or in combination, can improve GN-induced ARF by reducing the protein expression of IL-6, TNF-, and caspase-3