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St-Onge MP, Bosarge A, Goree LL, Darnell B
These findings establish a consensus-driven and transferable computational framework for chemotype-diverse agonist discovery at conformationally flexible GPCR targets, and revealed a pentapeptide with GLP-1-like efficacy as a promising lead for next-generation small peptide therapeutics
Research suggests that GLP-1 agents exert direct cardioprotective effects through anti-inflammatory mechanisms and improved endothelial function
notably, certain FAs can activate PPAR at physiologically relevant concentrations (145)
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