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Inflammatory Markers: Include CRP and homocysteine to measure systemic inflammation levels

Prescription medication requiring medical supervision Contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN2 Most common adverse events are gastrointestinal (nausea, diarrhea, vomiting) Dose escalation schedule important to minimize GI side effects Efficacy and Safety of the Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide in Patients With Type 2 Diabetes (SURPASS-1): A Double-Blind, Randomised, Phase 3 Trial , published in The Lancet (Rosenstock J et al., 2021

The Gs C-terminal, h5 helix (residues 370-394) is colored yellow

Who qualifies for the GLP-1 Bridge program

As discussed below, an approximately 50% reduction in the prevalence of PD after truncal vagotomy also supports the enteric pathway of PD 8,9