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Senescent cells promote inflammation and fibrosis by activating the p16/p21-Rb pathway and secreting senescence-associated secretory phenotype (SASP) factors, including IL-1, IL-6, IL-8, TGF-, plasminogen activator inhibitor (PAI), and insulin-like growth factor-1(IGF-1) (Lin et al., 2022

In the long term, such advancements could transform the prognosis for individuals with hemolytic anemia due to glutathione reductase deficiency

The most compelling candidates address multiple mechanisms simultaneously, which is why they show stronger results than compounds targeting a single pathway

It often starts in childhood and may continue as flare-ups in adulthood

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