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By activating GLP-1 receptors in the brain, it fundamentally changes the hormonal signals that drive hunger and satiety

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Pharmacol Rev

When a low dose of aspirin is administered orally (most commonly 81 mg), its context-sensitive drug disposition via the portal circulation combined with the difference in IC50 values for COX-1 vs COX-2 both contribute significantly to the high selectivity by which low dose oral aspirin inhibits platelet COX-1 vs other COX-2 found in other nucleated tissues such as the vascular endothelium (Pedersen & FitzGerald, 1984

It cannot prove the medication is free of bacterial endotoxins