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Graphical Abstract Similar content being viewed by others Introduction Diabetes mellitus (DM), which is regarded as the disease of the 21 st Century, is a growing epidemic health problem, characterized by elevated blood glucose as a result of either insufficient insulin production by the pancreas or a result of ineffective use of the insulin produced (WHO 2021)

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Further results of a single binge drinking mouse model (5 g/kg, 50%) showed that compared with wild-type mice, PTTG1 KO mice had more severe acute alcoholic liver injury and were accompanied by hepatic ERS aggravation and hepatocyte pyroptosis

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