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Share this article and the accompanying checklists with someone who is using a GLP-1 medication, considering medical weight management, or helping patients navigate substantial weight loss
A1C reduction comparison A network meta-analysis published in BMC Endocrine Disorders in 2024, analyzing 26 clinical studies, found the following A1C reductions compared to placebo: Tirzepatide 15mg: -2.24% A1C reduction Tirzepatide 10mg: -1.99% A1C reduction Tirzepatide 5mg: -1.82% A1C reduction Liraglutide 1.8mg: approximately -1.3% A1C reduction Liraglutide 1.2mg: -1.23% A1C reduction At the highest respective doses, tirzepatide reduces A1C by nearly twice as much as liraglutide
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weight loss at target dose (trial data) ~15% (same molecule) CV risk reduction labelled Label inherits evidence
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