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It is interesting to note that synthetic GHRPs had been discovered before the natural ones, which was part of the socalled reversed pharmacology approach, where synthetic GHSs had helped discover the GH secretagogue receptor and the natural GHS ghrelin was identified and isolated thereafter [2, 3, 4, 5, 6]

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Until such studies are conducted, the combination remains investigational and should be approached with appropriate caution, written informed consent, and consideration of FDA MedWatch reporting for any adverse events that occur with off-label combination use

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