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In another in vivo allergic rhinitis model, ovalbumin (OVA)-induced rats that were administered BBR (100 mg/kg) and CoQ10 demonstrated reduced nasal symptom scores, plasma IgE, IL-4, malondialdehyde, and nitric oxide (NO) levels and coincided with significant improvement in inflammation in nasal tissues subjected to histopathological immunohistochemical staining [55]

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These results suggested the possibility that amino-FMISO-GS may be the primary contributor to the radioactivity observed in 18 F-FMISO-PET images, in contrast to the conventional view of FMISO incorporation mainly through covalent binding to macromolecules [13]