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Building upon this core machinery, the glucosinolate pathway involves three additional enzymatic modules completing metabolic transformation: (1) CYP83A1 converts aliphatic aldoximes to thiohydroximates, (2) UGT74B1 mediates glycosylation of sulfated intermediates (requiring prior sulfation by SOT17/18), (3) the myrosinase-TGG1/2 system, in concert with epitope-specific proteins (ESPs), hydrolyzes stored glucosinolates into bioactive compounds like SFN upon tissue damage (41)

In rodents, broccoli sprouts or purified isothiocyanates reduce carcinogen-induced tumor burden across multiple tissues and decrease polyp formation in adenomatous polyposis coli multiple intestinal neoplasia (Apc Min ) models

Firmaet initierede desuden et studie (i samarbejde med Novo Nordisk, red.), hvor patienter med type 2-diabetes fik en intravens infusion med GLP-1 i syv dage

Plant Physiol Jun

PMID 19852790