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An overview of obesityrelated complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes

Tear fluid collection and analysis were reported in accordance with the TEAR-reporting guidelines 24

Mechanism of Action IGF-1 DES exerts its anabolic and metabolic effects through high-affinity binding to and activation of the IGF-1 receptor (IGF1R), a receptor tyrosine kinase that is widely expressed across virtually all cell types in the body and serves as the primary mediator of IGF-1's growth-promoting, anti-apoptotic, and metabolic actions

Cell Stem Cell 23 , 114122.e113 (2018)

Output declines with age, which is one reason body composition drifts unfavorably after the mid-30s even when diet and training hold steady