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The large number of polysubstance users (e.g., n = 11/14 cocaine, n = 6/14 THC) enrolled in the current MA cohort could have influenced findings and make it difficult to conclude findings are methamphetamine related

NAC may be useful when: Cysteine availability may be limiting The goal is to support internal glutathione synthesis Direct glutathione is poorly tolerated A clinician has identified a relevant medical or nutritional reason NAC does not guarantee that glutathione production will increase adequately

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More recently, osmotic pressure has been suggested to induce the systemic apoplastic release of signaling molecules like Glu 15

These changes were likely a result of FPN-induced oxidative stress, generation of ROS, mitochondrial dysfunction, and cytoskeleton disruption, which consequently led to cell death 62,63