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doi: 10.3389/fmolb.2022.925700 Received 21 April 2022 Accepted 29 June 2022 Published 22 July 2022 Volume 9 - 2022 Edited by Yan Chen, Second Xiangya Hospital, Central South University, China Reviewed by Jungang Xie, Huazhong University of Science and Technology, China Zhiyi He, Guangxi Medical University, China Updates Copyright 2022 Zhang, Yan, Lu and Zhou

Notably, in a recent chemical screen in the ferroptosis-sensitive HT-1080 N fibrosarcoma cells, seven out of eight PI3K/mTOR inhibitors suppressed the ferroptosis-inducing activity of erastin and sorafenib, but not the covalent GPX4 inhibitor, ML162 19