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While several proteomic studies have focused on identifying plasma biomarkers in patients with severe COVID-19 45,46,47,48,49,50,51 , relatively few have examined individuals with mild infectionsthe population that represents the majority of long COVID cases 52

Immunofluorescence staining was performed to assess MOTS-c expression

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Primarily, hypothyroidism itself adversely affects gastrointestinal physiology by diminishing gastric mucosal integrity and reducing gastric acid secretion, thereby impairing the efficient absorption of nutrients and trace elements critical for thyroid function, such as selenium, iodine, iron, zinc, and vitamin D (Shulhai et al., 2024)