Anti-human lung cancer activities and survey of glutathione reductase and glutathione S transferase inhibition properties with molecular modeling studies of 2-hydroxy-5-methyl-3-nitroacetophenone: a pre-clinical trial study More details Hide details 1 Department of Thoracic Surgery, Shaanxi Province Peoples Hospital, Xi an city, China 2 Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xian, China 3 Biology Department, College of Science, King Khalid University, Abha, Saudi Arabia 4 Zoology Department, College of Science, Damanhour University, Damanhour, Egypt 5 Pathology Department, College of Medicine, Taif University, Taif, Saudi Arabia Submission date: 2021-04-15 Final revision date: 2021-05-01 Acceptance date: 2021-05-03 Online publication date: 2021-05-14 Corresponding author Yawei Dou Shaanxi Province People's Hospital, China Introduction: The molecular docking method was found to calculate the biological activity of the 2-hydroxy-5-methyl-3-nitroacetophenone (2-H-5- M-3-N) molecule against the enzymes studied
In such settings, complex I inhibition fails to activate AMPK, resulting in enhanced ferroptosis sensitivity and synergistic antitumor effects when combined with radiotherapy 108
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