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To test for differentially activated regulons across treatments, a linear mixed-effects model was constructed with the SCENIC regulon activity score as dependent variable, treatment and time point as independent variables with interaction effects, and mouse and sequencing pool as random effects

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Clinician-Guided Vitamin B12 Program for Energy & Metabolic Support| This program is designed to support energy production, metabolic function, and overall vitality by targeting pathways involved in red blood cell formation and cellular energy metabolism

doi: 10.1186/1471-2334-6-15