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Changes must be made gradually to prevent withdrawal symptoms or breakthrough seizures, and patients cannot safely adjust doses on their own

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Although young people perceived e-cigarettes to be more harmful than conventional cigarettes, easy access from family and friends and the promotion of various appealing flavors in e-cigarettes may be prompting non-smokers to start using e-cigarettes

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The results were expressed in a qualitative score as safety margin from very small (e.g