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As highlighted in this review, flavonoids have emerged as promising therapeutic candidates due to their broad-spectrum actions on key pathophysiological processes in AD, including immune modulation, oxidative stress attenuation, barrier restoration, microbial regulation, pruritus relief, and regulation of programmed cell death

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Enhanced angiogenesis is a key feature of the Wolverine Stack in combined pre-clinical studies

Interestingly, alcohol administration caused a rather selective activation of NADPH oxidase (NOX), which, in turn, enhanced levels of reactive oxygen species (ROS) and 4-hydroxynonenal, but these were predominantly localized in astrocytes and microglia