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In the following decades, new forms of cell death, such as apoptosis, necroptosis, pyroptosis, and autophagy were discovered, each with its unique mechanism [5, 6]

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Atomic coordinates have been deposited in the Protein Data Bank (PDB) under accession codes 9PMD (OCTN2 inward-facing), 9PDQ (OCTN2 occluded) and 9PFB (OCTN2 ipratropium)

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In addition, the predictive performance of the final model was assessed by prediction-corrected visual predictive check (VPC) plots