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Like secretory IgA-deficient mice, we found that human COPD patients lacking secretory IgA had increased numbers of moDCs in their lungs

Next, TEER measurement was employed to assess the integrity of epithelial barrier through measuring their capacity to impede electric current applied across the epithelial layer, and apparent decrease of TEER was observed in CSE-exposed PBECs compared with normal cells, which was recovered by AZI concentration-dependently (Fig