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The Ozempic prescribing information directs clinicians to start at 0.25 mg once weekly for 4 weeks (tolerance-building), then increase to 0.5 mg, and if needed to 1 mg and 2 mg after at least 4 weeks at each level, using patient response and side-effect history to guide the ramp

And its patents have or are expiring in a number of other countries, including India just last week paving the way for cheaper, generic versions

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In particular, Lp(a) is thought to be a potential biomarker for anhedonia in male patients with unipolar and bipolar depression, although the precise mechanisms remain unclear, it is hypothesized that they may involve complex interactions among immune-inflammatory responses, lipoprotein profiles, and mood disorders [152]