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There are uneven shape irregular edges variance in color or discoloration larger than the size of a pencil erases change in size, contour, or coloration itching or seeping a sore that doesnt heal coloring that spreads from the spot to the surrounding skin redness of swelling that spreads to the surrounding skin pain, tenderness, or itchiness texture change in the mole such as scaliness, oozing, bleeding, or the appearance of a lump
[22] It is on the World Health Organization's List of Essential Medicines
7th edition
doi: Scafidi, S., Fiskum, G., Lindauer, S.L., Bamford, P., Shi, D., Hopkins, I
Gastrointestinal symptoms are the most frequent: nausea affects 22.8% of users, diarrhea 13%, and vomiting 9.1%, based on a 2026 meta-analysis of 101 RCTs covering 57,684 patients
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