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and 2) a trial-product estimand which includes data collected from all randomized participants prior to premature trial-product discontinuation or initiation of rescue medication ( SIDEBAR 2 )

An atomic model of BCRP was predicted by homology modeling based on the crystal structure of the bacterial multidrug exporter Sav1866, which suggested that BCRP had multiple drug binding sites (Hazai and Bikadi 2008, Muenster et al

and antroduodenal manometry, which is invasive but may provide some information as to the etiopathogenesis

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