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For that reason, this form is safe to use in patients with cobalamin metabolic diseases, tobacco amblyopia, or in pernicious anemia patients with optic neuropathy

Cold Sensitivity as a Metabolic Adaptation Signal Rather than a harmful side effect, increased cold sensitivity sometimes reflects your metabolism successfully adapting to lower caloric intake and improved energy efficiency

Results may vary depending on skin type and severity of hyper-pigmentation

As this is a phase 2 trial, the full long-term safety profile of retatrutide has not yet been established