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It acts on the receptors of two important hormones involved in postprandial blood sugar regulation: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

Increased insulin sensitivity (50) and the type 4 glucose transporters (GLUT4) cell surface translocation, which occurs independently of insulin administration, are the two main causes of this

In patients with inborn errors of metabolism, high HD infusion rates enable the administration of calories (along with ammonia clearance) to prevent catabolism 41,48

Distinguishing medication effects from pre-existing conditions and the psychological impact of weight loss itself remains challenging

Follow-up studies demonstrated that the insulin response resulting from carbohydrate feeding can be sufficient to increase the uptake of carnitine into the muscle (2)