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Hedgehog signals mediate anti-cancer drug resistance in three-dimensional primary colorectal cancer organoid culture

Molecular Medicine Reports , 2014

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At the beginning of the study, some patients used metformin, insulin, sulfonylureas, or iSGLT2, in addition to antihypertensive, hypolipidemic, and antiplatelet or antithrombotic agents [44]

In briefing documents for the meeting, the FDAs experts said there is a lack of evidence on effectiveness and safety to justify letting pharmacies make the peptides that the panel will review