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The quality and developmental potential of 1135 oocytes were subsequently evaluated in the laboratory after in vitro maturation (IVM), and 553 COCs were subjected to in vitro fertilization (IVF) and in vitro culture (IVC) to evaluate their fertilization potential, embryo development, and blastocyst quality

RG7112 selectively cleared senescent intervertebral disc cells, reduced senescence-associated secretory phenotype (SASP) factors, and improved disc matrix homeostasis in human disc tissue

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Systemic delivery via injection ensures adequate tissue concentrations while topical application provides direct contact with the scalp surface and upper follicle structures

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