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(2) Activated PLC may then hydrolyze membrane phosphatidylinositol 4,5-bisphosphate (PIP) into inositol 1,4,5-trisphosphate (IP) and diacylglycerol (DAG)

I also measure the signaling hormones TSH, LH & FSH, as well as things that can inhibit normal signaling, like estradiol, prolactin, inflammation, blood sugar, growth hormone, and micronutrient deficiencies

Figure 2 There is also now ample evidence demonstrating that insulin reaching the liver via the portal system plays an important role in making the liver more GH sensitive to IGF-I generation (41, 42)