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However, none of the treatments could fully restore the disc height or achieve the same MRI T2 signal intensity as the healthy disc [96]

Human germline mutations in glutarate metabolism highlight its fundamental biological role, with loss of function mutations in glutaryl-CoA dehydrogenase (GCDH) resulting in glutarate accumulation and glutaric aciduria type 1 (GA1)a rare autosomal disorder characterized by dystonia, developmental delay and often death in early childhood 10

However, NAC recordings demonstrate further decreases in power across the 120 Hz range when compared with saline recordings

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Following synthesis creatine is released to the blood where is is picked up, predominantly, by the brain and skeletal muscle cells through the action of the SLC family member transporter, SLC6A8