There is no clinical trial data comparing split versus single weekly dosing for semaglutide specifically, so this falls into the category of community-derived optimization
However, as research continued, erythrocytes were shown to affect vascular tone, immunity, redox homeostasis, and blood clotting
For example: Autoimmunity means the body's defense squad attacks its own team
Figure 2 Importantly, in the SELECT trial, differences in rates of cardiovascular events between semaglutide and placebo began to emerge within the first few months suggesting that weight loss alone may not account for the full benefits ( On the co-morbidities front, GLP-1R is not expressed in the liver and the data generated with semaglutide in NASH patients seems to support a lack of a direct antifibrotic effect (152)
Patients experience improved metabolic health with better blood sugar control, cholesterol levels, and reduced inflammation markers