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Before escalating to second- or third-line therapies, clinicians should first evaluate for potential confounding factors such as non-adherence, sub-optimal drug dosing, azathioprine hypermethylation, alternative etiologies, and co-existing conditions like celiac disease, metabolic dysfunction-associated steatotic liver disease, or ASC/overlap syndromes [29, 104]

Drekolia, M

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Moreover, the removal of biomarkers from the sample poses a major hindrance if the molecules to be detected form complexes with other macromolecules and precipitate, thus decreasing their final concentrations in pre-treated samples

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: a randomized, phase 2 trial