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Smith SR, Aronne LJ, Burns CM, Kesty NC, Halseth AE, Weyer C
It also modulates the activity of matrix metalloproteinases (MMPs) and their inhibitors, supporting balanced collagen remodeling rather than excessive breakdown or fibrosis
Subsequently, oral formulations and once weekly injections were developed in the 2010s and liraglutide was the first GLP-1 receptor agonist approved for the treatment of obesity in 2014
For gut-targeted indications, it may be the superior route because high local concentrations in the GI tract are exactly what you want
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