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However, it is important to note that erythrocytes generate ROS primarily as a result of (i) hemoglobin oxidation, which can be considered as an iron-mediated Fenton reaction, (ii) the activity of NAPDH oxidase and (iii) xanthine oxidoreductase, while in nucleated cells ROS are mainly generated in the mitochondrial electron transport chain
These peptides are present in various biological processes and can have significant effects on the health and functioning of the human body, including the oral cavity [32]
The SASP damages surrounding tissue, drives chronic inflammation, and converts neighboring healthy cells into senescent ones (van Deursen, 2014)
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