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Preclinical studies in rodent models have examined its interactions with nitric oxide signaling, angiogenic factors including VEGF, fibroblast migration, and collagen synthesis in various tissue types

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Funding This work was partially supported by the Puerto Rico Science, Technology and Research Trust award, and the following grants from the National Institutes of Health: NIGMS/MBRS Grant GM08224, NIMHD RCMI-Infectious and Global Diseases Center Grant G12MD007600, and NIMHD CCRHD-Tropical Emerging Infectious Diseases Research Center Grant U54MD007600