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Caloric intake monitoring becomes especially important to prevent the metabolic consequences of severe under-eating

some studies (including our own) have reported lower GABA+ levels in ACC (Ito et al., 2017), frontal cortex(Harada et al., 2011), SM1(Gaetz et al., 2014

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Given the poor bioavailability of oral NAD+ and its precursor vitamins through supplements (and why most wellness supplements have limited benefit), IV or subcutaneous routes are necessary to achieve the serum concentrations observed in the published research