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Additive effect on kidney outcomes including macroalbuminuria was also expected from AMPLITUDE-O substudy, however, additive effect of semaglutide and SGLT2i on the composite kidney outcomes without macroalbuminuria was not indicated in the FLOW substudy [50]

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10.1016/j.stemcr.2016.12.007 66 HuangC.-H.LinW.-K.ChangS

Notably, 1,568 transcripts were uniquely regulated in response to GLP-1MK-801 treatment, emphasizing that coordinated activity between the two receptor targets in vivo potently influences hypothalamic transcription

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