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Semimecanismo oxidativo [editar] En la mitad oxidativa del mecanismo, el residuo Cys 63 efecta un ataque nucleoflico sobre la unidad sulfuro ms cercana presente en la molcula de GSSG (accin promovida por His 467, la cual crea un puente disulfuro mixto (GS-Cys 58) y un anin GS

XZ and GL designed experimental protocols, interpreted data obtained from the experiments, and wrote the manuscript

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IC50 at 96 hours ranged from 5.5 to 38.4 nM in T-ALL and from 9.1 to 31.7 n in BCP-ALL ( Supplementary Figure 1 )