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Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter of the central nervous system that serves an important function in modulating neural excitability and that is often used to study response to stress and neural signaling

12 mg only if required, not by default the 12 mg arm carried a distinct side-effect profile

Although various attempts have been made to discover metabolite biomarkers for the diagnosis and treatment response of MDD, problems with sample size and consistency of results have limited clinical application

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