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The neuronal lineage commitment of NPCs, their exit from the cell cycle and further neuronal maturation is initiated by TFs of the basic helix-loop-helix (bHLH) family: Ngn2, NeuroD1 and NeuroD2 (Pleasure et al., 2000

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By focusing its action almost exclusively on stimulating a clean pulse of growth hormone, it sidesteps the primary mechanism that causes water retention in other peptides

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