Cognitive Enhancement Studies Cognitive improvement studies in 28-month-old mice (equivalent to elderly humans) using 10 mg/kg body weight administered 5x per week for 3 weeks demonstrated: Significantly faster escape hole finding in Box Maze tests (trials 4 and 5) Evidence of decreased brain inflammation Increased histone deacetylase 2 labeling indicating epigenetic pathway activation Preliminary reversal of age-related cognitive impairment Pain and Anxiety Modulation Anti-pain effects in mice at 0.5 mg/kg showed efficacy comparable to cimetidines human analgesic effects, affecting 7 anti-pain genes (increased) and 2 genes (decreased), with upregulated opioid receptors and related pain-modulating pathways
No washout period is typically required when switching from most oral medications to GLP-1 based injectables
Weight Loss Comparison: Metformin vs Ozempic Both metformin and Ozempic can promote weight loss as a side effect in individuals with type 2 diabetes who are overweight or obese, but the magnitude of results differs significantly
GLP-1RAs, which achieved great success in 2023 and draws peoples attention back to obesity treatments and GLP-1 therapies worldwide, was chosen as the breakthrough of year 2023 by Science [2]
No insurance approval, no membership fees, and no flat per-compound pricing increases mean predictable, affordable access to the same active compounds used in brand-name GLP-1 therapies