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doi: 10.1186/s13059-016-1053-6 Summary Keywords psoriasis, psoriatic arthritis, CD4 + T-cell, epigenetics, methylation, interferon, biomarker Citation Natoli V, Charras A, Hofmann SR, Northey S, Russ S, Schulze F, McCann L, Abraham S and Hedrich CM (2023) DNA methylation patterns in CD4 + T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis

Production requires a considerable metabolic input from ATP, methyl groups, and specific nutrients, including B vitamins, selenium, and amino acids

Human data: Human data comprises pharmacokinetic/pharmacodynamic study in volunteers and a completed Phase II trial for postoperative ileus (NCT00672074)

Shift to eating smaller meals more frequently vs

Dietary fibre influences the gut microbiota, especially by boosting the abundance of SCFA-producing bacteria (62)