While the beneficial effects of low IGF-1 action on aging seems well supported by data in model systems 6,7 and unique human populations 13,16 , a broader examination of the literature suggests that a more nuanced, complex, and controversial relationship exists between IGF-1, aging, and disease, which is indicative of the pleiotropic actions attributed to IGF-1 in cells and tissues 12,19
If youre using it for general recovery and gut health, consider cycling 3 months on, 1 month off
Understanding the distinct mechanisms and indications of each treatment is essential when considering their use together, particularly as Mounjaro's effects on appetite and food intake may impact overall nutritional status
SR: Data curation, Writingoriginal draft
Borruto et al