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As in the previous recommendations by the ADA and EASD (73, 74), life-style intervention (with patient education and motivation, increase of physical activity, and healthy eating) is still in the beginning and center of therapy, followed by pharmacological therapy with metformin (7074)

The studies must compare the effects of GLP-1 agonists and placebo on body weight and HbA1c at baseline and following GLP-1 agonists in patients with T1DM exclusively

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Selenium Supplementation Improved Cardiac Functions by Suppressing DNMT2-Mediated GPX1 Promoter DNA Methylation in AGE-Induced Heart Failure