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As well, obtained findings showed that ALC can partially reverse hippocampal levels of MDA, ROS, SOD, TNFa, NF-kB, TLR4, GFAP, and caspase 1

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For differentiation, 12 10 5 PBMCs were seeded in 1 ml complete medium containing 1 penicillinstreptomycin and 2050 ng ml 1 GM-CSF (PeproTech) per well in 24-well plates for 46 days, with medium changed every other day

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The biological effect is thus decoupled from the plasma half-life and the magnitude of the dose, provided the minimal signaling threshold is met [4, 5]