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Type 2 Diabetes Improved Glycemic Control : Cagrilintide reduces hemoglobin A1C by up to 2.2%, improves insulin sensitivity, and decreases glucagon levels, contributing to better glucose management ( 3 )

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Maintenance doses are typically 1 mg every 2-3 months for life High-dose oral therapy (1000-2000 micrograms daily) may be effective in selected patients with pernicious anaemia under clinical supervision, as passive diffusion can compensate for absent intrinsic factor, though this is not routine first-line treatment in the UK The water-soluble nature of B12 means that high-dose supplementation carries minimal risk of toxicity , making it a safe option for individuals with confirmed or suspected deficiency