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In addition, immunosuppressive cells target effector cells through the expression of immune checkpoint proteins, e.g., the PD-1/PD-L1 and CTLA-4 proteins, which suppress the activation of T cells and prevent antigen-presentation
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This synergy is the scientific rationale for the combination
Ferrostatin-1 potently inhibits the release of high mobility group box protein (HMGB)-1, a classical marker of necroinflammatory response, in cell models and human skin explants after UVB irradiation, thus confirming that ferroptosis is a key element of the necroinflammatory process in keratinocytes
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